https://pchsieh.com/tags/multi-agent-systems/Multi-Agent SystemsHugoBlox Kit (https://hugoblox.com)en-usMon, 01 Jun 2026 00:00:00 +0000https://pchsieh.com/media/icon.svghttps://pchsieh.com/tags/multi-agent-systems/https://pchsieh.com/projects/cfdna-agent/Mon, 01 Jun 2026 00:00:00 +0000https://pchsieh.com/projects/cfdna-agent/<p><strong>Role:</strong> Project Lead · Northwestern University (Remote) · Jun 2026 – Oct 2026</p> <p>cfDNA-Scientist is a self-evolving multi-agent system that autonomously proposes, implements, and evaluates biomedical feature-extraction code in executable research environments, using cell-free DNA data.</p> <h2 id="what-i-did">What I did</h2> <ul> <li><strong>Built the multi-agent system.</strong> Agents coordinate hypothesis generation, feature implementation, verification, critique, and curation, running the generated code in executable research environments.</li> <li><strong>Designed a literature-search workflow.</strong> A preliminary workflow identifies established cfDNA fragmentomic features, builds a feature catalog, and validates baseline performance.</li> <li><strong>Evaluated on breast cancer detection.</strong> cfDNA-Scientist reached a cross-validated <strong>AUC of 0.916</strong>, compared with <strong>0.831</strong> for the baseline under the same evaluation protocol.</li> </ul> <p>See the for how this fits into my broader work.</p>